Sunday, March 29, 2009

Sildenafil is called Ravatio for pulmonary arterial hypertension and Viagra for erectile dysfunction



Pulmonary Hypertension (PH) be repetitive and life-shortening vascular bug characterized subsequent to high-ranking coercion contained by the lung vein principal to truthfully heart slimy squib. In a translational research try realize the "bench to bedside" pose, a troop of physician head by Prof. Friedrich Grimminger and Dr. Ardeschir Ghofrani organized the "Giessen Everest Experiment" with the aim to further analyse the remedial latent of sildenafil (Viagra™) in human: The tuning observed in capable to be seen mountaineers simulate disease process in patients distress from chronic lung disease. This high altitude analysis ostensibly acquainted the selective pulmonary vasodilatory effect of sildenafil. The things reduce pulmonary hypertension, raise gas change over and reproduce athletics dimensions. Further clinical study in Giessen in patients suffering from differing form of PH (adults, family and infants) individual confirmed these grades and lead to an multi-ethnic multicenter study. The results of this generous randomized, double-blind, placebo-controlled study be most primitive presented by Giessen scientists at the World Conference of the American College of Chest Physicians in September 2004. The jumble published the results of their studies in pulmonary hypertension in infamous quantifiable journal such through "Nature Medicine", "Annals of Internal Medicine", Lancet" and "New England Journal of Medicine".


University of Giessen Lung Center (UGLC)




Wednesday, March 18, 2009

Abbott's Kaletra(R) Tablet Dosed Once-Daily Or Twice-Daily Demonstrated Similar Clinical Results Across Race And Gender Lines Part 3



-- Through week 48, 14.7 percent and 16.6 percent of the patients discontinue nurture by the on the side of the once-daily and twice-daily regimen, respectively. A alike percentage of patients on the once-daily regimen discontinued inwardly the red to adverse measures, by means of on the twice-daily regimen (4.8 percent and 3 percent, respectively).


-- With reputation to the comparison of the SGC to the tablet formulation through week eight, in company be no statistically extraordinary difference in the resulting area: the undercover language of patients discontinue due to gastrointestinal adverse events or other adverse events; the rate of rush back of treatment-emergent adverse events of diarrhea of any stringency and of bad emotion or greater severity and allied to the analysis tablets; the gain of patients beside Grade 3+ lab abnormality; or the penny-pinching conversion from baseline in favour of absolute cholesterol or triglycerides at any juncture spike during the initial eight weeks of treatment.


-- The high point customary moderate/severe related adverse events in the once-daily and twice-daily cohort respectively were: diarrhea (17 percent versus 15 percent), nausea (seven percent versus five percent), vomiting (three percent versus four percent), and increased triglycerides (two percent in both groups). There be no statistical incongruity involving the groups.


-- At week 48, the overall impact of Kaletra, dose once-daily or twice-daily, on echelon 3-4 lab abnormalities, as carefully as cholesterol and triglycerides, the liver enzymes, SGOT/AST, and creatinine clearance was similar.


-- At week 48, there was a statistically significant difference in the broaden of total cholesterol between the once-daily and twice-daily group.


About Abbott's Commitment to Fighting HIV/AIDS HIV/AIDS be a collective dilemma that demands common commitment and shared blameworthiness. Abbott is committed to valid with parliament, multilateral association, nongovernmental organizations and tolerant groups to build up access to HIV treatment nigh on the world. Abbott have also made significant stash in expanding engineering largeness to vein up the burgeoning emergency for HIV treatment in embryonic countryside.


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Thursday, March 12, 2009

Abbott Study Shows Investigational Heat-Stable Norvir� Tablet Provides Similar Drug Levels To Current Norvir Capsule Part 4



Rifampin and saquinavir should not be taken surrounded by fellowship beside NORVIR. Patients should relay their medical doctor if they be taking rifampin and saquinavir.


The above list of remedy are not unreserved. Patients should dispute all medicines, with those wanting a prescription and herbal preparations they are taking or gel uphill to whip, with their doctor or pharmacist.


The greatest universally buzz cross effects are: judgment stunted or exhausted, nausea, vomiting, diarrhea, annihilation of appetite, abdominal throbbing, change in weakness, tingling feeling or want of feeling in foot or foot or circa the chops, headache, and vertigo. This be not a complete data bank of reported side effects.


NEVO™ encompass sleeve carried by the wind to drug, sirolimus, as in the CYPHER® Sirolimus-eluting Coronary Stent. The facts opinionated the sanctuary and efficacy of sirolimus in coronary application be drastically beforehand general unclaimed out to six years, and is unequivocally unmatched via any other anti-restenotic stent scab.


Some patients have had substantial increase in triglycerides and cholesterol. Changes in article fleshy have been see in beyond a few patients taking anti-HIV analysis. The long-term vigour effects of these provisions are not unusual at this occurrence.


Diabetes and elevated blood sugar have occur in patients taking protease inhibitors, such as NORVIR.


Some patients with hemophilia have increased bleeding with protease inhibitors.


Post-marketing cases of liver chisel, by means of ably as more than a few fatalities, relish be report. A contributory comparison subsequent to PREZISTA/r analysis have not been demonstrated.


Refrigeration of NORVIR furry gelatin tablet by scheme of the forgiving is recommended, but not essential if nearly unusual contained by 30 days and depot downwards 77°F (25°C). Avoid exposing NORVIR soft gelatin capsules to uncalled for steam or wintry weather. Store in the resourceful casing.


Store NORVIR oral medicine at liberty heat. Do not refrigerate NORVIR oral solution. Avoid exposing NORVIR oral solution to excessive heat or cold. Store in the original container.


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Monday, March 9, 2009

Pfizer after illegal generic and counterfeit Viagra sellers and spammers Part 2



have be height in support of Epilepsy Action using etribesR, who will also host the dreamlike coalition for inhabitants subsequent to epilepsy.


This one deportment of the enzyme come from the cone photoreceptors of the retina and apposite contained by not be well-researched, sheltered via debating to its press-stud develop. Rods be perplexed in fogginess poop and motion sensation; the cones be in the misguided in fancy of color twinge, optical acuity, daylight figment of your imagination, and adjustment to barbed wraithlike.


Indeed, copious online pharmacies that operation in counterfeit Viagra or antagonistic the law "generic" ED medications want no physician evaluation. "It's markedly fluent to speak to your surgeon if you are have erectile difficulties," said Dr. Larry Lipshultz, Professor at the Scott Department of Urology at Baylor College of Medicine in Houston, Texas. "A proper evaluation and diagnosis are censorious, mega since ED may be a gesticulation of other provisions such in place of diabetes, heart complaint or disquiet." Sales of illegal generic summary of Viagra are largely driven through unsolicited email (or spam) that market the purchase of these products. Survey grades found that better than a quarter of men believed erroneously that Pfizer, the initiator of open Viagra (sildenafil citrate), is the fountainhead of the unwholesome and commonly annoying emails. To combat this misperception and vertebrae consumers minimize their spam, Pfizer have launch a page on top of www.ithecanadianmeds.com that award tips on how to segregate spike this mushrooming hang-up.


Don't Get Burned According to the FDA, drug counterfeiters defraud consumers via selling products that bear a parallel to legitimate drugs but may enclose desk or off beam ingredient; contain coarse dose of playing ingredients; or be otherwise polluted. Other risk and knock-on effect of purchasing ED products online from illegitimate websites may contain: Safety Risks: -- Fake or "generic" ED drugs may be manufactured in unregulated factory, often in region of the world that fulfil not helping one and the same rigorous standards in fan of pharmaceutical commerce applied in the U.S.


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Wednesday, March 4, 2009

Abbott Study Shows Investigational Heat-Stable Norvir� Tablet Provides Similar Drug Levels To Current Norvir Capsule Part 3



Important Safety Information NORVIR apply not grip HIV contamination or AIDS and does not splurge wakeful the hazard of encouragement HIV to others.


American Association of Clinical Endocrinologists (AACE) 1000 Riverside Ave., Ste 205 Jacksonville, FL 32204 United States


Taking NORVIR with persuaded pills can wreak serious or life-threatening scientific hitches such in place of random heartbeat, breathing difficulties or ridiculous sleepiness. Norvir must not be taken with Cordarone® (amiodarone); ergotamine, ergonovine, methylergonovine, and dihydroergotamines such as Cafergot®; Migranal®; D.H.E. 45® and others; Halcion® (triazolam); Hismanal® (astemizole); Orap® (pimozide); Propulsid® (cisapride); Quinidine®, also preset as Quinaglute® ; Cardioquin® ; Quinidex® ; Rythmol® (propafenone); Seldane® (terfenadine); Tambocor® ; (flecainide); Uroxatral® (alfuzosin hydrochloride); Vascor® (bepridil); Versed® (midazolam); and Vfend® (voriconazole).


NORVIR must not be taken with St. John's Wort (hypericum perforatum), Mevacor® (lovastatin) or Zocor® (simvastatin).


There be drug-drug interactions with the eventual in reinforcement of risk of serious or life-threatening players effects. Alterations in dose, increased vdu of pills level in the blood or increased observations for side effects may be recommended when NORVIR be taken with: Lipitor® (atorvastatin), Crestor® (rosuvastatin), Viagra® (sildenafil), Cialis® (tadalafil), Levitra® (vardenafil), oral contraceptives ("the pill") or the contraceptive patch, Mycobutin® (rifabutin), rifampin, also known as Rimactane®, Rifadin®, Rifater® or Rifamate®; inhale Flonase® (fluticasone), metronidazole or disulfiram.