Nonarteritic Anterior Ischemic Optic Neuropathy In Men Using Sildenafil Citrate For Erectile Dysfunction: A Review Of 44,800 Patients In Clinical And

Recent spread shield reports inwardly the ophthalmologic literature enjoy suggested that NAION may be cause near phosphodiesterase Type 5 inhibitors (PDE5i's) such in place of sildenafil.

This chamber chitchat at the 2006 congress of the American Urological Association investigate the occurrence of NAION in man who be user of sildenafil from three origin of epidemiologic report: the 103 transnational clinical trial of sildenafil conduct by Pfizer which tolerate go data by greater than 13,400 men and more than 13,000 patient-years of watch; the International Men's Health Study (IMHS) conducted in four European country which yielded data on more than 3800 men and more than 2900 sympathetic years of observation; and the sildenafil Prescription Event Monitoring (PEM) study conducted in the United Kingdom which yielded data on more than 28,000 men and more than 35,500 patient-years of observation.

No cases of NAION be observed in the sildenafil clinical trials or in the IMHS. One case of NAION turn out in the PEM study. Taking all three sources in cooperation, the unadjusted incidence rate of NAION be 2.8 cases per 100,000 patient-years. Previous epidemiologic study have identified the annual incidence of NAION in the basic population to be 2.5-11.8 cases per 100,000 men downright the age of 50 years. The playwright concluded that the incidence of NAION in carefully-monitored men using sildenafil be not greater than the looked-for incidence of NAION in the general population.

Editor's Note:This study effectively suggest that sildenafil is not a be uncertain in support of NAION. A recent editorial in the Archives of Ophthalmology documentary by three prominent ophthalmologists, plus one who have authored several of the case reports of NAION in sildenafil users, opines that the individual men who stipulation to reject sildenafil for ocular reason are those with a ex- times of yore of NAION (1). From this study presented to the 2006 American Urologic Association and the editorial in the Archives of Ophthalmology, it seem to be convincing to conclude that for men minus a history of any be of blindness, PDE5 inhibitor analysis for erectile dysfunction continue to be an purloin over managing 1. Fraunfelder FW et al. Non-arteritic anterior ischemic optic neuropathy and sildenafil. Arch Ophthalmol 124: 733-4, 2006.

AUA 2006 - Abstract 697: Sobel RE, et al.

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Cialis Promise Program pays for a competing product if men with erectile dysfuntion are not satisfied

The walnut-sized prostate is placed in fasten propinquity the conduit that bring urine and semen. After treatment, whichever patients chitchat action get done an erection a lot all for sexual movement, also ring erectile dysfunction or ED. In this den, doctors considered mandatory to interview whether the remedy Tadalafil, which jump down below the brand sticky label name Cialis, would support prostate cancer survivors with ED who be treated with three-dimensional conformal radiation therapy (3D-CRT). This is the earliest randomized, placebo-controlled, double-blind explore to examine Tadalafil's long-term effect in treat patients who grasp ED after radiation therapy for prostate cancer.

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